What is affected...
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Cockayne Syndrome attacks the gene ERCC8 (excision repair cross-complementing rodent repair deficiency complementation group 8)
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and ERCC6 (excision repair cross-complementing rodent repair deficiency complementation group 6)
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Both of these genes are responsible for producing proteins that are involved in repairing damaged DNA through the transcription coupled repair mechanism. |
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How its affected...
- These genes go through a mutation before a child is even born. The abnormal genes recieved from both parents inhibit the genes' ability to complete their job which leads to the damage of DNA which ultimately leads to all of Cockayne syndrome's other damages and symptoms.
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Where its affected...
- Chromosome 5 is the home of gene ERCC8
- Chromosome 10 is the home of gene ERCC6
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